The University of Manchester have developed a new series of small molecule compounds, specifically designed to stimulate eNAMPT dimerization

One of the key compounds in a number of cellular process is Nicotinamide Adenine Dinucleotide (NAD), of which Intracellular NAMPT (iNAMPT) plays a key role in maintaining the levels of. NAMPT inhibitors have been known for some time, and many researchers have attempted to use these limiters to inhibit the growth of tumours. However, the high toxicity of these inhibitors has limited their clinical use to cancer applications, despite the fact they could be used in a number of other treatments.

Extracellular NAMPT (eNAMPT/PBEF/visfatin) have been implicated in the pathophysiology of a range of chronic inflammatory diseases, such as diabetes, cardiovascular disease, Alzheimer’s disease, and osteo and rheumatoid arthritis, where there is an emerging relationship between eNAMPT levels and disease state in both preclinical models and patients.

A computer-generated model of an eNAMPT moduator.
eNAMPT modulator.

 

The University of Manchester have developed a new series of small molecule compounds, specifically designed to stimulate eNAMPT dimerization and have demonstrated these have potent activity leading to a corrective effect in in vitro and in vivo phenotypic models of diabetes.

A crystal structure of the NAMPT protein bound to one of their compounds (left) alongside an image of an islet showing improvement in beta cell number following compound treatment (right).
A crystal structure of the NAMPT protein bound to one of their compounds (left) alongside an image of an islet showing improvement in beta cell number following compound treatment (right).

 

Nine slides of eNAMPT cells.

eNAMPT cells.

 

The team are currently carrying out further preclinical proof of concept studies in diabetic, cardiovascular and psoriasis models to evidence the broad potential applications of our compounds. Patent applications are being prepared, as is the business plan to support spinout of this technology.

For more information, please contact:

Sonia Nikolovski
sonia.nikolovski@uominnovationfactory.com
+44 (0)161 606 7297 (office)*
+44 (0)7760 342 765 (mobile)

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